Hugues Roest Crollius @ENS_ULM will talk about Comparative genomics in vertebrates: from models to applications. #C3BIPasteur #LargeAudience
Upcoming Events : C3BI Seminars – Large audience – 07/02/2015 at 02:00 pm in Retrovirus room – LWOFF (22)
Date : 07/02/2015 at 02:00 pm
Location : Retrovirus room – LWOFF (22)
Speakers/Trainers : Hugues Roest Crollius, Head of the Genome Evolution and Dynamics Group (DYOGEN) from Ecole Normale Supérieure
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Comparative genomics in vertebrates: from models to applications.
Genomic rearrangements, first observed more than a century ago, are one of the most obvious differences between genomes of closely related eukaryotes. Genomic rearrangements modify the order and organisation of genes because of evolutionary breakpoints caused by chromosome inversions, translocations, fusions or fissions. They do not occur randomly in genomes and are known to be associated with specific genomic features, yet the forces that promote them have remained elusive. Importantly, chromosome breakpoints are mutational events that may cause or may be associated with human pathologies. I will present two facets of comparative genomics in vertebrates that exploit the properties of genome rearrangements. The first illustrates how considering breakpoints in an evolutionary framework can lead to statistical models that formulate strong and plausible explanations for the mechanisms that cause breakpoints. The second postulates that genomic regions that do not rearrange during evolution are likely to be under strong functional constraints, thus revealing potential long-range cis-regulatory domains. Methods to identify such regions were experimentally tested both in model organisms and with respect to their involvement in human developmental disorders. Comparative genomics is a powerful multidisciplinary approach to decipher genome biology, and the recent acceleration in genome sequence production is paving the way for exciting discoveries. Website