Hierarchical functional genomics to interpret genome variation and dissect complex disease architecture

EVENT : C3BI SEMINAR

HIERARCHICAL FUNCTIONAL GENOMICS TO INTERPRET GENOME VARIATION AND DISSECT COMPLEX DISEASE ARCHITECTURE

Main speaker : Emmanouil Dermitzakis, from Functional Population Genomics and Genetics of Complex Traits Laboratory (FunPopGen)
Department of Genetic Medicine and Development / Director: Health 2030 Genome Center Universite de Geneve

Date : 05-04-2018 at 02:00 pm
Location : Auditorium Francois Jacob – BIME (26), Institut Pasteur, Paris


Molecular phenotypes inform us about genetic and environmental effects on cellular and tissue state. The elucidation of the genetic basis of gene expression and other cellular phenotypes is highly informative for the impact of genetic variants in the cell and the subsequent consequences in the organism. In this talk I will discuss recent advances in key areas of the analysis and integration of the genomics of gene expression, chromatin and cellular phenotypes in human populations and multiple tissues from various cohorts including the GTEx consortium and how this assists in the interpretation of regulatory networks and human disease variants. I will also discuss how these recent advances are informing us about the impact of regulatory variation in cancer.


Due to security policy in Institut Pasteur, please register before if you plan to come to this meeting