Hub members Have many expertise, covering most of the fields in bioinformatics and biostatistics. You'll find below a non-exhaustive list of these expertise
Searched keyword : Epidemiology and public health
Related people (2)
Developing and evaluating bioinformatic tools for: – next generation sequencing data – genome analysis & comparison Specialties:Genome & Transcriptome Bioinformatics
Data managementData VisualizationGenomicsNon coding RNASequence analysisTranscriptomicsGenome analysisBiostatisticsProgram developmentScientific computingData and text miningBiosensors and biomarkersEpidemiology and public health
- Identification of non-coding RNAs under the control of the PerR regulators(Nadia BENAROUDJ - Biology of Spirochetes) - Closed
- Tissue-resident stromal cell heterogeneity(Lucie PEDUTO - Stroma, Inflammation and Tissue Repair) - Closed
- Role of small non coding RNAs in the adaptive response to oxidative stress in pathogenic Leptospira(NADIA BENAROUDJ - Biology of Spirochetes) - Closed
Thomas is a biostatistician who holds an engineering degree in Agronomy (Agrocampus Ouest, Rennes, France). He also holds a Ph.D. in biostatistics from Université Pierre et Marie Curie for his work on the spread of nosocomial pathogens on contact networks. During his Ph.D at INSERM, he investigated how high-resolution dynamical contact data could support infection-tracing conducted using more traditional approaches in healthcare settings, e.g. routine swabbing and genetic characterization of strains detected in patients or healthcare workers. He developed a new statistical framework to test the correlation between dynamic close-proximity interaction networks and biological carriage data. While at INSERM, he also developed the R0 package for R that aimed at implementing several computation methods used in estimating reproduction parameters for emerging transmissible diseases. After working as a statistical modeller for a private company in the pharmaceutical industry, he joined the Hub in 2016 as a statistician and is now involved in the projects of the Malaria: parasites and hosts unit headed by Ivo Mueller.
ModelingBiostatisticsScientific computingApplication of mathematics in sciencesClinical researchEpidemiology and public health
- Deciphering the role of viral transmission on the establishment of persistent infections(Alessandro TORRI - Viruses and RNA Interference) - Pending
- Mosquito vector competence for Zika virus(Anna-Bella FAILLOUX - Arboviruses and Insect Vectors) - Closed
- Tests serologics anti-CNF1(Daniel GUERIN - Bacterial Toxins) - Closed
Related projects (5)
It has been shown that methylation can act as a kind of memory of the immune system. For patients with co-infections, it is of particular importance to know when to begin an anti-retroviral therapy, especially if they are already infected with tuberculosis. The goal of this study is to find hyper or hypo methylated loci related to the reaction of HIV patients (co-infected or not) to different kind of treatments.
As a result of combined climate change and globalization (increased flow of travelers and goods), the distribution of the mosquito Aedes albopictus is expanding significantly outside tropical regions. Ae. albopictus has already established stable colonies in 20 European countries (https://ecdc.europa.eu/en/publications-data/aedes-albopictus-current-known-distribution-june-2018). Being the main mosquito that can be incriminated in the transmission of chikungunya, dengue, and zika viruses in Europe, Ae. albopictus were responsible for the first autochthonous cases in France and Italy. Accordingly, the European countries that are infested with Ae. albopictus are under the risk of arboviral diseases outbreak. The vector competence analysis of European Ae. albopictus is pivotal for evaluating the potential risk of diseases transmission. In this study, we analyzed the viral susceptibility of several European Ae. albopictus populations from Croatia, Greece, Montenegro, Italy, Switzerland, and also China (as a control), for chikungunya, dengue, and zika viruses. The results indicated that the European Ae. albopictus were able to transmit chikungunya and dengue viruses whereas they were not an efficient vector for zika virus.
Lyme borreliosis (LB) is an important tick-borne disease which can cause a broad range of symptoms mainly affecting the skin, the nervous system and the joints. It is caused by bacteria of the Borrelia burgdorferi sensu lato (s.l.) complex. In Europe, at least five genospecies are known to be pathogenic, namely Borrelia afzelii, Borrelia garinii, B. burgdorferi sensu stricto, Borrelia spielmanii and Borrelia bavariensis. In order to assess the health burden, data on the incidence of all the different clinical manifestations are required. The National Reference Centre for Borrelia collected epdiemiological, clinical and biological data from general practioners and hospitals of patients bitten by Ixodes ticks from 2003 to 2011. This large amount of data needs statistical analyses both univariate and univariate in order to obtain a global and precise vision of all the elements allowing us to understand this disease, both in the complexity of its symptoms and its management but also in the context of its prevention.
Modulation of infectious diseases transmission by climate conditions must be investigate in Sahel to prevent epidemics. Registration of data on flu transmission and on rainfalls+ temperature was conducted over the last ten years by the Flu national reference center in Niamey. Time series analysis must be conducted to investigate the correlation between the number of cases and climatic conditions.
Le projet a pour objectif de développer une page web pour présenter les travaux de modélisation de la pandémie de la COVID-19 au grand public.