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Searched keyword : Aspergillus fumigatus
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The increased incidences of invasive fungal infections coupled with the paucity of available antifungal drugs for treatment have driven the search for novel agents with unique fungal targets. Studies in the pathogenic yeast Candida albicans have attempted to identify novel transcription factors that may be associated with regulating antifungal drug tolerance. In order to investigate novel regulators of cell wall permeability and antifungal responses in the pathogenic mold Aspergillus fumigatus, we employed a library composed of deletions in nearly 400 transcription factors. A screen for mutants that demonstrated altered susceptibility to congo red and calcofluor white, two cell wall binding agents, identified three hypersensitive and three resistant mutants. RNA-seq analysis is ongoing in order to identify and analyze the genes/pathways that play a role in the modification of cell wall permeability.
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