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Hub Members
Searched member : Natalia PIETROSEMOLI

Natalia PIETROSEMOLI
Dr. Natalia Pietrosemoli is an Engineer with a M. Sc. in Modeling and Simulation of Complex Realities from the International Center for Theoretical Physics, ICTP and the International School of Advanced Studies, SISSA (Triest, Italy). During her M. Sc. internships she mostly worked in modeling, optimization, combinatorics and information theory applied to medical imaging. In 2012 she got a Ph. D in Computational Biology from the School of Bioengineering of Rice University (Houston, TX, US), where she specialized in computational structural biology and functional genomics. Her doctoral thesis “Protein functional features extracted with from primary sequences : a focus on disordered regions”, contributed to a better understanding of the functional and evolutionary role of intrinsic disorder in protein plasticity, complexity and adaptation to stress conditions. As part of her Ph. D., Natalia was a visiting scholar in two labs in Madrid: the Structural Computational Biology Group at the Spanish National Cancer Research Centre (CNIO), where she mainly worked in sequence analysis and the functional-structural relationships of proteins, and the Computational Systems Biology Group at the Spanish National Centre for Biotechnology (CNB-CSIC ), where she studied the functional implications of intrinsically disordered proteins at the genomic level for several organisms, collaborating with different experimental and theoretical groups. In 2013, she joined the Swiss Institute of Bioinformatics as a postdoctoral fellow in the Bioinformactics Core Facility. Her main project consisted in the molecular classification of a rare type of lymphoma, which involved the integration of transcriptomic, clinical and mutational data for the identification of molecular markers for classification, diagnosis and prognosis. This work was performed in collaboration with the Pathology Institute at the University Hospital of Lausanne (CHUV). In November of 2015 Natalia joined the Hub Team @ Pasteur C3BI as a Senior Bioinformatician. Natalia is especially interested in the integrative analysis of different omics data, both at large-scale and for small datasets, and loves collaborating in interdisciplinary environments and having feedback from her fellow experimental colleagues. Currently, she’s coordinating several projects performing functional and pathway analysis at the genomic level. By grouping genes, proteins and other biological molecules into the pathways they are involved in, the complexity of the analyses is significantly reduced, while the explanatory power increases with respect to having a list of differentially expressed genes or proteins.
KeywordsAlgorithmicsData managementGenomicsImage analysisMachine learningModelingProteomicsSequence analysisStructural bioinformaticsTranscriptomicsDatabaseGenome analysisBiostatisticsScientific computingDatabases and ontologiesApplication of mathematics in sciencesData and text miningGeneticsGraphics and Image ProcessingBiosensors and biomarkersClinical researchCell biology and developmental biologyInteractomicsBioimage analysisOrganisms
Projects (32)
- #19102 : Exploring pathogenic mechanisms of chronic inflammatory disease: unresolved issues in IL-23/IL-17 biology (YAHIA HANANE - Immunoregulation) - In Progress
- #17789 : Study of the role of cyclic dimeric guanosine mono-phosphate (c-di-GMP) in the regulation of virulence and biofilm formation in Leptospira interrogans (Gregoire DAVIGNON - Other) - In Progress
- #16720 : Global BioID-based SARS-CoV-2 proteins proximal interactome unveils novel ties between viral polypeptides and host factors involved in multiple COVID19-associated mechanisms (Yves JACOB - Molecular Genetics of RNA Viruses) - In Progress
- #14989 : Mitochondrial polarization identifies functionally mature human NK cells (Laura SURACE - Innate Immunity) - Awaiting Publication
- #14332 : Proteomic analysis of the intracellular compartments containing Brucella abortus (Javier PIZARRO-CERDA - Yersinia) - In Progress
- #13848 : Secretome Analysis of OIS IL6KO SASP (Mathieu VON JOEST - Cellular Plasticity And Disease Modelling) - In Progress
- #13496 : Microscystis transcriptome (Muriel GUGGER - Collection of Cyanobacteria) - Awaiting Publication
- #13408 : Proteome remodeling induces by the Cytotoxic Necrotizing Factors 1 (Landry Laure TSOUMTSA - Bacterial Toxins) - Closed
- #13078 : Determination of the transcriptome controlled by the two-component system BvrR/BvrS using dominant positive and negative BvrR mutants (Javier PIZARRO-CERDA - Yersinia) - Awaiting Publication
- #12997 : Identifying subpopulation-specific signatures of tuberculosis persistence for enhanced diagnostics. (Giulia MANINA - Microbial Individuality and Infection) - Awaiting Publication
- #12996 : Analyse transcriptionnelle du cellules cancéreuse intestinal vs normales après co-culture avec la bactérie associée au cancer Streptococcus gallolyticus (Ewa PASQUEREAU - Biology of Gram-Positive Pathogens) - Closed
- #12641 : Functional interactomics of SKAP2 (Jean-François BUREAU - Functional Genetics of Infectious Diseases) - Closed
- #12246 : functional enrichment of RNA processing factors associated with proteins of influenza viruses (Caroline DEMERET - Molecular Genetics of RNA Viruses) - Awaiting Publication
- #11975 : Analyse d’expression de gènes de la réponse immune par voies fonctionnelles (Frédérique MICHEL - Other) - Closed
- #8494 : NOXO1 interacting partners in intestinal epithelial cells under inflammatory and infectious conditions (Benoit MARTEYN - Molecular Microbial Pathogenesis) - Closed
- #8302 : Metabolic characterization of ILCs under homeostatic or stress conditions (Laura SURACE - Department of Immunology) - Closed
- #8263 : Performing Gene Ontology Analysis on RNAseq data in Aedes aegypti (Sarah MERKLING - Insect-Virus Interactions) - Closed
- #8202 : Transcriptomic analysis of blood cells from ebola infected patients (Stéphanie REYNARD - Biology of Viral Emerging Infections) - Closed
- #7930 : Gene expression profiling in Kupffer cells (Yu WEI - Hepacivirus and Innate Immunity) - Awaiting Publication
- #7836 : Graphical representation of co-expressed genes in various datasets (PANTHIER JEAN-JACQUES - Mouse Functional Genetics) - Closed
- #7820 : Study of the early pathogenesis during Lassa fever in cynomolgus monkeys and its correlation with the outcome (Sylvain BAIZE - Biology of Viral Emerging Infections) - In Progress
- #7757 : Comparative analysis of transcriptomic and proteomic data to study RNA and protein expression regulation during RVFV infection in mice. (Boissiere MAGALI - Mouse Functional Genetics) - Pending
- #7750 : Gene ontology analysis of RNAseq data from uninfected and Leishmania-infected mouse macrophages (Eric PRINA - Molecular Parasitology and Signaling) - Closed
- #7704 : Comparative analysis of gene expression in different human cell clones (PABLO GARCIA GUTIERREZ - Nuclear Organization and Oncogenesis) - Closed
- #7213 : Activation of plasmacytoïd dendritic cells by arenaviruses : transcriptomic analysis (Justine SCHAEFFER - Biology of Viral Emerging Infections) - Closed
- #7074 : Gene Ontology and sequence analysis of proteomics data on mycolactone effects on dendritic cells. (Jean-David MOREL - Immunobiology of Infection) - Closed
- #6313 : Molecular analysis of muscle stem cells (Francesca PALA - Stem Cells And Development) - Closed
- #5567 : Rift valley fever NSm protein functional study (Boissiere MAGALI - Structural Virology) - Awaiting Publication
- #3907 : secretome analysis of human intestinal cells during shigella invasion (nathalie SAUVONNET - Molecular Microbial Pathogenesis) - Closed
- #3255 : ANALYSIS OF TRANSCRIPTIONNAL MODULATIONS INDUCED IN C57BL/6 BONE-MARROW DERIVED MACROPHAGES INFECTED BY LEISHMANIA AMAZONENSIS IN PRESENCE OR ABSENCE OF INFLAMMASOME-ACTIVATING CONDITIONS (Herve LECOEUR - Molecular Parasitology and Signaling) - Closed
- #3223 : Transciptomic analysis of dendritic cell response during Lassa virus infection (Justine SCHAEFFER - Biology of Viral Emerging Infections) - Closed
- #2479 : Molecular analysis of muscle stem cells (Shahragim TAJBAKHSH - Stem Cells And Development) - Closed