Pierre LECHAT

I have been involved in genomic projects for prokaryotic and human genetic studies (GWAS) since 1998. Currently, I am working on novel visualization techniques to explore large and highly complex data sets. I have develop a web based graphical user interface, called SynTView (http://genopole.pasteur.fr/SynTView/) to visualize biological features in comparative genomic studies. The tool allows interactive visualization of microbial genomes to investigate massive amounts of information efficiently. The software is characterized by the presentation of synthetic organisations of microbial genomes and the visualization of polymorphism data. I am extending this work into designing novel dynamic views for comparative analysis of viruses in emerging disease.

• #13196 : Chikungunya virus adaptation to a low temperature in a French population Ae. albopictus (Rachel BELLONE - Arboviruses and Insect Vectors) - Pending
• #12929 : Single nucleotide polymorphisms and genome organization in members of the genus Yersinia (Javier PIZARRO-CERDA - Yersinia) - Pending
• #11075 : characterization of RNA virus populations from untargeted NGS in natural infections samples (Etienne SIMON-LORIERE - Evolutionary Genomics of RNA viruses) - In Progress
• #8328 : Experimental evolution of Chikungunya and Zika viruses’ strains to study emerging variants. (Marco VIGNUZZI - Viral Populations and Pathogenesis) - In Progress
• #7964 : Identification de SNP entre 2 souches bactériennes (Laurent DEBARBIEUX - Molecular Biology of Gene in Extremophiles) - In Progress
• #7841 : Research of SNPs to explain the non virulent phenotype of a mutant of L. interrogans serovar Manilae L495 affecting the expression of a protein not involved in virulence (Catherine WERTS - Biology and Genetics of Bacterial Cell Wall) - Closed
• #7834 : Role of PerR-regulated oxidative stress response in pathogen Leptospira virulence (Nadia BENAROUDJ - Biology of Spirochetes) - Pending
• #7607 : JASS: an online tool for the joint analysis of GWAS summary statistics (Hugues ASCHARD - Center of Bioinformatics, Biostatistics and Integrative Biology) - Awaiting Publication
• #5667 : Comparative analysis of the virulence plasmids of Shigella Spp. and entero-invasive Escherichia coli (Claude PARSOT - Molecular Microbial Pathogenesis) - Closed
• #4863 : Recherche de SNP chez une souche de leptospira biflexa d'interêt (Bourhy PASCALE - Biology of Spirochetes) - Closed
• #4541 : Prediction of RNA-RNA interactions between a family of GC-rich ncRNAs and nascent transcripts of virulence genes in Plasmodium falciparum (Anna BARCONS SIMON - Biology of Host-parasite Interactions) - Closed
• #3327 : Listeriomics - Development of a web platform for visualization and analysis of Listeria omics data (Pascale COSSART - Bacteria-Cell Interactions) - Closed
• #3312 : Determination of SNPs in 6 genomes of Leptospira kirschneri serovar grippotyphosa (Perrine HUGON - Biology of Spirochetes ) - In Progress
• #3100 : SNP based analysis of French Bordetella pertussis isolates: comparison of isolates producing all the vaccine antigens to isolates producing only some of them. (Valérie BOUCHEZ - Molecular Prevention and Therapy of Human Diseases) - Closed
• #3086 : Bio-informatics support for the LeiSHield project (Gerald SPAETH - Molecular Parasitology and Signaling) - In Progress
• #2525 : Characterization of an unusual Leishmania major HSP70-related protein (Gerald SPAETH - Molecular Parasitology and Signaling) - Closed
• #2490 : Analyses of SNP diversity of Legionella pneumophila strains (Carmen BUCHRIESER - Biology Of Intracellular Bacteria) - Closed
• #2249 : Phylogenetic analysis of the Leishmania HSP70 protein family (Gerald SPAETH - Molecular Parasitology and Signaling) - Closed
• #380 : Genomic approach for the identification of new targets of antimycobacterial drugs (Maria Virginia BUCHIERI - Mycobacterial Genetics) - Closed