Thomas BIGOT

I joined the C3BI Hub in 2016 after a curriculum widely dedicated to Bioinformatics studies, and more precisely to Phylogeny and Evolution, topics of my PhD thesis. At Institut Pasteur, I am involved in projects dealing with sequences homology : alignments, hmm profiles, making homologous family databases, kmers signatures. I am also a developer (Python / C++) with a solid interest in optimization as well as in developing usable tools for final user such as automated pipeline for metagenomics sequence analysis. I’m currently embedded in Marc Eloit’s team (80% of my work time). My main task in this team is to develop strategies to identify, in their metagenomics samples, new pathogens, or new combination pathogen / symptoms. The rest of my time, I manage small projects and participate to the Hub life. I am currently experimenting with functional programming (for now, using Python) and its applicability to bioinformatics issues.

• #19239 : Human nasopharyngeal virome variation in healthy and disease individuals. (Toshiki ERI - Innate Immunity) - Pending
• #17266 : RNA virus discovery (Artem BAIDALIUK - Evolutionary genomics of RNA viruses) - Pending
• #13699 : DNMT and RNMT in Leishmania (Gerald SPAETH - Molecular Parasitology and Signaling) - In Progress
• #13287 : Targetting the function of a hypothetical protein (Dariusz CZERNECKI - Structural Dynamics of Macromolecules) - Pending
• #13259 : Defective interfering viral genomes of shrimps' viruses (Anastassia KOMAROVA - Viral Genomics and Vaccination) - Awaiting Publication
• #12674 : DNMT orthologs in Leishmania (Suzanne LAMOTTE - Molecular Parasitology and Signaling) - Closed
• #11075 : characterization of RNA virus populations from untargeted NGS in natural infections samples (Etienne SIMON-LORIERE - Evolutionary Genomics of RNA viruses) - Closed
• #7901 : Automatic detection of antibiotic resistance genes (Olivier CHESNEAU - Other) - In Progress
• #7820 : Study of the early pathogenesis during Lassa fever in cynomolgus monkeys and its correlation with the outcome (Sylvain BAIZE - Biology of Viral Emerging Infections) - In Progress
• #7283 : Detection of virulence Genes and genes of interest in Bacillus cereus (Dominique CLERMONT - Department of Microbiology) - Closed
• #6333 : Identification of new or unexpected pathogens, including viruses, bacteria, fungi and parasites associated with acute or progressive diseases (Marc ELOIT - Biology of Infection) - In Progress