Project #10143
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#10143 : AIMyc: Analysis of the Impact of antibiotics, antifungals on the Mycobiome of allogeneic stem cell recipients.
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Name of Applicant : Alanio Alexandre
Date of application : 03-10-2017
Unit : Molecular Mycology
Location : Duclaux
Phone : 2154701130
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Project context and summary :

Patients undergoing hematopoietic stem cell transplant (HSCT) are known to be at risk of invasive candidiasis despite antifungal prophylaxis with Candida dissemination occurring from the gut mycobiome to the bloodstream. These patients are given antifungal drugs, antibiotics known to impact growth and favor the selection of some intrinsically resistant fungal species. The AIMyc project proposes to depict the impact of antifungal, antibiotics treatments on the diversity of species within the mycobiome by leveraging the unique opportunity to follow the mycobiome of HSCT patients overtime and to compare it to a 1000 healthy individuals cohort (LabEx), using state-of-the-art genomic techniques. This study should lead to new knowledge in mycobiome dynamics and allow to develop strategies to restore an efficient intestinal flora or to prevent invasive diseases. In addition, new biomarker strategies to detect fungal components in plasma samples will be explored based on the microbiome data.

Related team publications :
Alanio A, Bretagne S. Performance evaluation of multiplex PCR including Aspergillus-not so simple! Med Mycol. 2017 Jan 1;55(1):56–62.
A. ALANIO, O. Cabaret, E. Sitterlé, J.-M. Costa, S. Brisse, C. Cordonnier, and S. Bretagne, “Azole preexposure affects the Aspergillus fumigatus population in patients.,” Antimicrob Agents Chemother, vol. 56, no. 9, pp. 4948–4950, Sep. 2012.
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Project Type : Short
Status : Closed
Global Satisfaction for this application : Excellent (5/5)

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