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Project #10357
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#10357 : Environmental and human surveillance of polioviruses, VDPVs, and other enteroviruses in Madagascar and the impact during the switch from tOPV to bOPV
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Organisms :

Group :
Name of Applicant : Patsy Polston
Date of application : 19-10-2017
Unit : Biology of Enteric Viruses
Location : Darre-02-08a
Phone : 01-40-61-33-21
@ Mail : patsy.polston@pasteur.fr
@ PI-Mail : francis.delpeyroux@pasteur.fr

Project context and summary :

Poliomyelitis has been a major public health concern and currently, efforts are being made towards eradicating wild poliovirus type 2 (WPV2). A global switch from trivalent oral poliovirus vaccine (tOPV) to bivalent oral poliovirus vaccine (bOPV without PV2) has taken place in countries, like Madagascar, where epidemics of recombinant type 2 pathogenic circulating vaccine-derived polioviruses (cVDPVs) were reported in the last decade. This occurs when low polio vaccine coverage and high population density allows the circulation, genetic drift and intertypic recombination process of vaccine attenuated PV2 that can thus become pathogenic. In an attempt to monitor the decline of OPV2 following the switch and the possible effect on other enteroviruses in the human population, environmental and human surveillance was conducted before, during, and after the switch in three regions of Madagascar. PV2, in particular cVDPVs and other enteroviruses will be genetically characterized. These data will support monitoring efforts and confirm the elimination of type 2 PV strains that have been implicated in outbreaks in this country.


Related team publications :
Delpeyroux F et al., 2013, Eradication of poliomyelitis and emergence of pathogenic vaccine-derived polioviruses: from Madagascar to Cameroon
Razafindratsimandresy R et al., 2013, Reemergence of recombinant vaccine-derived polioviruses in healthy children, Madagascar
Rakoto-Andrianarivelo M et al., 2007, Co-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar
Service Delivery
Project Manager : amine.ghozlane@pasteur.fr
Project Type : Long
Status : In Progress


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