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Project #10895
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#10895 : CNF-domain containing toxin family
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Organisms :

Group :
Name of Applicant : Emmanuel Lemichez
Date of application : 16-01-2018
Unit : Anaerobe Bacteria and Toxins
Location : Guerin 01 04
Phone : 0145683044
@ Mail : emmanuel.lemichez@pasteur.fr

Project context and summary :

Alterations of the cellular proteome over time due to spontaneous or enzymatic deamidation of glutamine (Gln) and asparagine (Asn) residues is a probable source of aging-related diseases. In particular, deamidation of a conserved glutamine in all GTPases of the Ras superfamily that are essential for cellular GTP turnover, confers to these molecular switches gain-of-function properties that can stimulate oncogenic signaling pathways. The CNF1 toxin produced by pathogenic Escherichia coli, a prevalent resident in human gut microbiota, is an example of a bacterial factor with the potential to cause somatic “oncogenic mutation” of Rho GTPases through deamidation. Development of holistic approaches for personalized medicine to monitor healthy microbiota could led to improved public health and increased lifespans.


Related team publications :
Lemichez E. New Aspects on Bacterial Effectors Targeting Rho GTPases. Curr Top Microbiol Immunol 2016;399:155-174.
Washington EJ et al. What a difference a Dalton makes: bacterial virulence factors modulate eukaryotic host cell signaling systems via deamidation. Microbiol Mol Biol Rev 2013;77:527-539.
Buetow L et al. Structure of the Rho-activating domain of Escherichia coli cytotoxic necrotizing factor 1. Nat Struct Biol 2001;8:584-588.
Service Delivery
Project Manager : stephane.descorps-declere@pasteur.fr
Project Type : Short
Status : In Progress


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