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Project #10913
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#10913 : Finding and Predicting CRISPR-Cas9 Efficiency
Topics :
Organisms :

Group :
Name of Applicant : Jerome Wong Ng
Date of application : 18-01-2018
Unit : Synthetic Biology
Location : Monod, 4e ├ętage, 26-04-05A
Phone : 0781190628
@ Mail : wong@pasteur.fr
@ PI-Mail : david.bikard@pasteur.fr

Project context and summary :

CRISPR-Cas systems provide immunity to bacteria and archaea. One of the reasons these systems have attracted so much attention in the past few years is due to the discovery of nucleases among the Cas proteins that are guided by small RNAs to bind and degrade homologous DNA. The introduction of breaks in DNA that can be repaired either in a controlled or uncontrolled manner now is a widely used method to introduce mutations in genomes. We are interested in probing the CRISPR-Cas system efficiency for different targets.


Related team publications :
Service Delivery
Project Manager : christophe.becavin@pasteur.fr
Project Type : Short
Status : Closed
Publication : 10.1371/journal.pgen.1007749


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