Project #10920
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#10920 : Phylogenetic analysis of HHD-PDZ containing proteins
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Name of Applicant : Nicolas Wolff
Date of application : 19-01-2018
Unit : Channel Receptors
Location : Metchnikoff-1st-1023
Phone : 8872
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Project context and summary :

Harmonin Homology Domains (HHD) are protein-protein interaction domains primarily identified in a few proteins involved in earing and vision. Only six HHD-containing proteins encompassing 9 HHD domains have been identified so far in mammals. Four of these proteins are neuronal and also contain PDZ domains, exhibiting different HHD-PDZ modular organisations. This project aims at 1) searching orthologs with HHD domains, 2) establishing the phylogenetic tree of HHD-containing proteins and 3) understanding how various patterns of HHD-PDZ modules from the previsouly mentioned neuronal proteins originated.

Related team publications :
Delhommel F, Cordier F, Bardiaux B, Bouvier G, Colcombet-Cazenave B, Brier S, Raynal B, Nouaille S, Bahloul A, ..., Wolff N., Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem, Structure, 2017, S0969-2126(17)30266-6.
Bahloul, A., Pepermans, E., Raynal, B., Wolff, N., Cordier, F., England, P., … Petit, C., Conformational switch of harmonin, a submembrane scaffold protein of the hair cell mechanoelectrical transduction machinery, FEBS Letters, 2017, 591(15), 2299–2310.
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Project Type : Short
Status : Closed
Publication : 10.1186/s12859-021-04116-5

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