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Project #10939
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#10939 : Microbiota dysbiosis in human colon cancer
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Organisms :
Group :
Name of Applicant : Iradj SOBHANI
Date of application : 30-01-2018
Unit : Other
Location : APHP-Hopital henri Mondor and Institut Pasteur
Phone : 0149814358
@ Mail : iradj.sobhani@aphp.fr

Project context and summary :

Colon cancer (CRC) is frequent, of bad prognosis, whilst the cost continues to increase. Environmental factors play a role in the majority of sporadic CRC cases. All members of a family share common environment factors and gene determinants. In about 5% of CRC, dominant role of gene is identified as Lynch Syndrome (LS) with mutation in DNA mismatch repair (MMR) genes. Considering the high lifetime risk of developing carcinomas in these individuals, it is relevant to study whether modifiable lifestyle factors can affect the cancer risk. Faecal microbiota that (all bacteria present in the colon) is specific to each individual and highly influenced by environment factors. It boosts CRC development in animal, exerts modulation on inflammation and immunity in the tumour microenvironment and its changes (dysbiosis) is associated with higher CRC risk. It therefore is considered as a mirror of individual “environment-host” interactions. PI of the present project initiated the APHP and EMBL scientific collaboration in 2009 that yielded these results. Fusobacteria (Fu) and particularly, nucelatum animalis and vicentii (FuN) species, could be considered as “bad” bacteria because appeared more prevalent in CRC. We presently whish identifying and quantifying all significant bacteria associated to CRC as community for evaluating predictive values at baseline up to a subsequent occurrence (longitudinal analysis) of high grade dysplasia (HGD), polyps and/or CRC.


Related team publications :
http://onlinelibrary.wiley.com/doi/10.15252/msb.20145645/abstract
Sobhani etal, PloS One 2011
Amiot et al; PloS One 2014
Service Delivery
Project Manager : amine.ghozlane@pasteur.fr
Project Type : Medium
Status : Pending


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