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Project #10948
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#10948 : Insight into the Immune System: A bioresource and data-sharing platform to study chronic inflammatory diseases (IsIShare)
Topics :
Organisms :
Group :
Name of Applicant : helene laude
Date of application : 31-01-2018
Unit : Other
Location : Lwoff First floor Room 09A
Phone : 0145688394
@ Mail : helene.laude@pasteur.fr
@ PI-Mail : marie-noelle.ungeheuer@pasteur.fr

Project context and summary :

Chronic inflammatory systemic diseases (CIDs) are a burden to humans because of life-long debilitating illness, increased mortality and high therapy costs. CIDs’ increasing prevalence in western countries has indeed placed them at the third rank of morbi-mortality causes. Unfortunately, available treatments are poorly targeted and non-curative. That is partly linked to a complex and largely ununderstood pathophysiology. Genetic susceptibility clearly plays a role. Genes linked to the immune system have been identified, but causal genes remain mostly unknown and other factors such as intestinal microbiota have also been implicated. The complexity of CIDs’ pathophysiology suggests that a holistic approach is the most susceptible to help make significant progress. Our project intends to take advantage of recent technical progress and development of informatics tools to set up a transversal approach. High-resolution sequencing technology indeed quickly produces large amounts of accurate data. Besides, new integrative informatics tools allowing storage and integrative analysis of this resulting high amount of data are now available. We intend to set-up a CID’s network allowing the gathering and extensive analysis of data related to immuno-genetic determinants, immune repertoire and microbiota from individuals suffering from one of the three major interlinked CIDs, namely Hidradenitis Suppurativa (HS), Crohn’s disease (CD) and Spondyloarthropathy (SpA) as compared to healthy volunteers.


Related team publications :
(1) The Microbiological Landscape of Anaerobic Infections in Hidradenitis Suppurativa: A Prospective Metagenomic Study. 1. Guet-Revillet H, Jais JP, Ungeheuer M-N, Coignard-Biehler H, Duchatelet S, Delage M, Lam T, Hovnanian A, Lortholary O, Nassif X, Nassif A, Join-Lambert O. The microbiological landscape of anaerobic infections in Hidradenitis suppurativa: a prospective metagenomic study.Clin Infect Dis. 2017 Jul 15;65(2):282-291
(2) Lamas B, Richard ML, Leducq V, Pham HP, Michel ML, […], Ryffel B, Beaugerie L, Launay JM, Langella P, Xavier RJ and Sokol H. CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands. Nature Medicine 2016. Jun;22(6):598-605
(3) Costantino F, Talpin A, Said-Nahal R, Leboime A, Zinovieva E, Zelenika D, Gut I, Charon C, Izac B, Weissman M, Chiocchia G, Reveille J, Breban M, Garchon HJ. A family-based genome-wide association study reveals an association of spondyloarthritis with MAPK14. Ann Rheum Dis. 2017, 76:310-4.
Service Delivery
Project Manager : vincent.guillemot@pasteur.fr
Status : Closed
Global Satisfaction for this application : Excellent (5/5)


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