Project #11317
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#11317 : Role of ATM in EBV latency
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Name of Applicant : Marc Lecuit
Date of application : 29-03-2018
Unit : Biology of Infection
Location : Duclaux RDC haut
Phone : +33631031200
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Project context and summary :

Ataxia-telangiectasia (AT) is an autosomal recessive disorder characterized by a biallelic mutation of the Ataxia Telangiectasia Mutated (ATM) gene. The ATM protein is involved in a very large number of cellular functions (over 700 substrates), mainly DNA repair, cell cycle regulation, mitochondrial and oxidative metabolism, as well as regulation of gene expression. The majority of hematological malignancies occurring in AT patients are non-Hodgkin's B lymphomas and Hodgkin's lymphomas. The association with the Epstein-Barr virus (EBV) is found in 50 to 100% of these cases according to the histological subtype. EBV is a widespread virus in human populations with a prevalence greater than 90% and is associated with the development of lymphomas in immunocompromised patients. We will study the transcriptome of EBV-infected cells in ATM patients, in order to determine the impact of ATM on EBV infection control.

Related team publications :
Suarez, et al. 2015. Incidence, Presentation, and Prognosis of Malignancies in Ataxia-Telangiectasia: A Report from the French National Registry of Primary Immune Deficiencies. Journal of Clinical Oncology 33 (2):202–8.
Suarez F, Lortholary O, Hermine O, Lecuit M. Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation. Blood. 2006 Apr 15;107(8):3034-44
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Project Manager :
Project Type : Short
Status : Closed
Publication : 10.1186/s13023-021-01904-3
Global Satisfaction for this application : Excellent (5/5)

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