Project #11681
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#11681 : Genetic traits involved in the regulation of NK cell and ILC homeostasis and NK cell-mediated anti-tumor functions
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Name of Applicant : Christian Vosshenrich
Date of application : 30-04-2018
Unit : Innate Immunity
Location : Metchnikoff 4045
Phone : 3757
@ Mail :

Project context and summary :

This project aims at identifying novel genetic traits that regulate the anti-tumor activities of NK cells and homeostasis of NK cells and other ILC using an unique mouse resource, the Collaborative Cross (CC). CC is a panel of recombinant inbred mice derived from randomized breeding of eight laboratory inbred strains combining high genetic diversity with the advantage of inbred mouse strains. We have identified CC strains that diverge in their anti-tumor immune responses and are characterizing the molecular mechanisms responsible for these differences. Ultimately, these diverse genetic traits may lead to the development of novel therapies for cancer.

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Project Type : Short
Status : Closed
Publication : 10.1073/pnas.2018834118
Global Satisfaction for this application : Excellent (5/5)

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