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Project #11681
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#11681 : Genetic traits involved in the regulation of NK cell and ILC homeostasis and NK cell-mediated anti-tumor functions
Topics : Organisms :
Group : Name of Applicant : Christian Vosshenrich Date of application : 30-04-2018 Unit : Innate Immunity Location : Metchnikoff 4045 Phone : 3757@ Mail : christian.vosshenrich@pasteur.fr
Project context and summary :
This project aims at identifying novel genetic traits that regulate the anti-tumor activities of NK cells and homeostasis of NK cells and other ILC using an unique mouse resource, the Collaborative Cross (CC). CC is a panel of recombinant inbred mice derived from randomized breeding of eight laboratory inbred strains combining high genetic diversity with the advantage of inbred mouse strains. We have identified CC strains that diverge in their anti-tumor immune responses and are characterizing the molecular mechanisms responsible for these differences. Ultimately, these diverse genetic traits may lead to the development of novel therapies for cancer.
Related team publications : Service Delivery
Project Manager : pascal.campagne@pasteur.frProject Type : ShortStatus : In Progress