Project
Project #11966
Step by step one goes very far
Organisms :
Group : Name of Applicant : Oliver Bischof Date of application : 05-07-2018 Unit : Nuclear Organization and Oncogenesis Location : LWOFF 3rd floor 307 Phone : 0140613307@ Mail : oliver.bischof@pasteur.fr
Project context and summary :
Cellular senescence is a complex stress response that durable (yet not irreversibly) arrests cell proliferation and is accompanied by widespread changes in chromatin structure, metabolism and gene expression including the production and secretion of a plethora of inflammatory factors. Cellular senescence plays beneficial roles during embryonic development, tissue regeneration, and tumor suppression. Paradoxically, it is also considered a major contributor to aging and age-related diseases, the latter mostly through its inflammatory phenotype, the so-called SASP (senescence-associated secretory phenotype). The proposed work aims at integrating time-resolved transcriptome, ChIP-seq, and ATAC-seq datasets into a comprehensive understanding of senescence-associated gene regulation.
Related team publications :