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Project #12069
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#12069 : Heterogeneity of tissue resident stromal cells
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Organisms :
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Name of Applicant : Douaa Al-Dhahri
Date of application : 28-07-2018
Unit : Department of Immunology
Location : Metchnikoff-RDC-05
Phone : 0663498860/ ext: 8233
@ Mail : douaa.dhahri@pasteur.fr
@ PI-Mail : lucie.peduto@pasteur.fr

Project context and summary :

Tissue resident stromal cells form the scaffold of all organs. In addition, they provide signals for proper positioning, survival and interaction of a number of other cell types, such as immune cells. Following tissue damage, the stromal microenvironment play an esssential role to organize inflammation and tissue repair. The stromal vascular fraction (SVF) of most organs is composed of immune cells, endothelial cells, mesenchymal stromal cells and tissue stem cells. Our lab investigates the impact of specific subsets of mesenchymal stromal cells (MSCs) on the different components of the SVF, at homeostasis and during the repair process. We have previoulsy identified specific subsets of MSCs that have an essential role in inflammation, tissue fibrosis or maintenance of the intestinal stem cell niche (Peduto et al., 2009; Dulauroy et al., 2012; Stzepourginski et al., 2017). This project aims at further deciphering the heterogeneity of the stromal compartment in different organs at homeostasis or following injury, and establish its transcriptional signature.


Related team publications :
Peduto et al., J immunol, 2009
Dulauroy et al., Nat Med, 2012
Stzepourginski et al., PNAS, 2017
Service Delivery
Project Manager : claudia.chica@pasteur.fr
Project Type : Medium
Status : In Progress


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