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Project #12502
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#12502 : Toxin induced dephosphorylation of H3S10
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Group : Name of Applicant : Melanie Hamon Date of application : 06-11-2018 Unit : Chromatin and Infection Location : Calmette - 4 - 01a Phone : 8968@ Mail : hamon@pasteur.fr
Project context and summary :
During infection with bacteria, secretion of toxin induces histone modifications in the host cell. One such modification is dephosphorylation of histone H3 on serine 10. We have characterized this modification and the bacterial factors that are important for inducing it. The bacterial toxin listeriolysin O is one such factor. However the role of this modification is unknown. Genome wide analysis of the genes or genetic regions marked with dephosphorylated H3 will help us reveal the function of this modification during infection.
Related team publications :Hamon M.A., Batsche E, Regnault B, Tham TN, Seveau S, Muchardt C, Cossart P. Histone modifications induced by a family of bacterial toxins. Proc Natl Acad Sci. 2007. 104: 13467-72.
Hamon, M. A., and P. Cossart. K+ efflux, is required for histone-H3 dephosphorylation by Listeria LLO and other pore forming toxins. Infect Immun. 2011. 79(7):2839-46
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