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Project context and summary :
During infection with bacteria, secretion of toxin induces histone modifications in the host cell. One such modification is dephosphorylation of histone H3 on serine 10. We have characterized this modification and the bacterial factors that are important for inducing it. The bacterial toxin listeriolysin O is one such factor. However the role of this modification is unknown. Genome wide analysis of the genes or genetic regions marked with dephosphorylated H3 will help us reveal the function of this modification during infection.Related team publications :
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