Project

Project #12619
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Topics :

Biostatistics Data and text mining Data integration Exploratory data analysis

Organisms :

Bacteria Bacteria Virus Parasite Human Parasite Virus Other different pathovars of E. coli, Shigella spp., Salmonella spp., Campylobacter jejuni, Vibrio cholerae, Other Giardia, Entamoeba, Microsporidia, Ascaris, Trichuris, Cryptosporidum Other Rotavirus, Adenovirus Pan, Adenovirus 40/41, Rotavirus, Astrovirus, Norovirus GII

Group :

STATS

Name of Applicant : Pascale Vonaesch
Date of application : 23-11-2018
Unit : Molecular Microbial Pathogenesis
Location : Duclaux, Bertrand, 1er étage, salle 01B
Phone : poste 9576
@ Mail : pascale.vonasch@pasteur.fr
@ PI-Mail : philippe.sansonetti@pasteur.fr

Project context and summary :

This project is integrated in the analysis of the gut ecosystem of children implicated in the AFRIBIOTA project, a translational project performed within a consortium of researchers and medical doctors from the Central African Republic, Madagascar, France and Canada (see https://research.pasteur.fr/fr/program_project/the-afribiota-project/). AFRIBIOTA aims at understanding the risk factors and pathophysiological changes underlying chronic child malnutrition as manifested through delayed growth. Within the project submitted, we aim at assessing a possible link between asymptomatic pathogen carriage, gut inflammation and stunted growth of children included in the study site in Antananarivo, Madagascar.

Related team publications :

Vonaesch et al., PNAS 2018: Stunted childhood growth is associated with decompartmentalization of the gastrointestinal tract and overgrowth of oropharyngeal taxa.

Vonaesch et al., BMC Paediatrics 2018: Identifying the etiology and pathophysiology underlying stunting and environmental enteropathy: study protocol of the AFRIBIOTA project.

Vonaesch et al., FEMS Microbiology Reviews 2018: Pathogens, microbiome and the host: emergence of the ecological Koch’s postulates.

Project Manager : vincent.guillemot@pasteur.fr
Project Type : Short
Status : In Progress

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