Project #12670
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#12670 : Genome-wide interactions between HP1g and RNA.
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Name of Applicant : Christophe Rachez
Date of application : 12-12-2018
Unit : Epigenetic Regulation
Location : 66-04-05
Phone : 0145688880
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Project context and summary :

The three HP1 proteins (Heterochromatin Protein 1 alpha, -beta, -gamma) are epigenetic markers of heterochromatin, the condensed, repressed form of chromatin. They are typically known to associate to the di-/tri-methylated lysine 9 of histone H3 (H3-K9me2/3), a repressive histone mark, HP1s are therefore linked to chromatin silencing. But on the other hand, HP1g has been shown to localize within the body of coding genes in correlation with their transcriptional activity. We have identified functional links between HP1g and chromatin-associated RNA on gene models, but we are now dissecting these links on a genome-wide basis.

Related team publications :
Saint-André V, Batsché E, Rachez C, Muchardt C. 2011. Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons. Nat Struct Mol Biol. 18(3):337-44.
Muchardt C, Guilleme M, Seeler JS, Trouche D, Dejean A, Yaniv M. 2002. Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha. EMBO Reports 3:975–981
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Project Manager :
Project Type : Short
Status : Closed
Publication : 10.15252/embr.202052320
Global Satisfaction for this application : Excellent (5/5)

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