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Project context and summary :
Helicobacter pylori is a Gram-negative pathogen whose infection results in various gastric diseases including gastric cancer in Humans. Current drug therapy against the bacteria involves a combination of two antibiotics, proton-pump inhibitor and a Bismuth salt. Introduction of bismuth has resulted in increased success rate compared to traditional therapies without bismuth salt. H. pylori is a genetically variable bacteria with high rates of mutations and recombination. Interestingly till now, there is no report of Bismuth resistance in H. pylori clinical isolates. Very limited data is available about the mechanism of entry and the anti-bacterial action of bismuth in H. pylori. We selected laboratory strain of H. pylori for bismuth resistance in order to identify/determine its effect in H. pylori. The resistance strains exhibit different levels of susceptibility to bismuth compared to the parent strain. Comparative genomics will shed light on the mode of resistance(s) acquired in H. pylori strains. Identification of genes and pathway involved in bismuth resistance will be useful to determine the mechanistic details of bismuth's action.Related team publications :
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