Project #12929
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#12929 : Single nucleotide polymorphisms and genome organization in members of the genus Yersinia
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Name of Applicant : Javier PIZARRO-CERDA
Date of application : 05-02-2019
Unit : Yersinia
Location : Duclaux - 1st floor - Room 01A
Phone : 0145688326
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Project context and summary :

Members of the genus Yersinia include environmental as well as pathogenic bacteria. Pathogenic species (Y. pestis, Y. pseudotuberculosis and Y. enterocolitica) have historically been targets for research aimed at understanding how bacteria evolve into diverse mammalian pathogens. The advent of large-scale population genomic studies has greatly accelerated the progress in this field, revealing how gene gain, gene loss and genome rearrangement events have impacted evolution of enteropathogenic bacteria. In the context of the sequencing of many novel genomes of Yersinia spp., within this project we are interested in the generation of a bioinformatic tool that will allow us to compare and visualize single nucleotide polymorphisms as well as genome organization in members of the genus Yersinia, in order to better understand genomic events that drive evolution within this bacterial species.

Related team publications :
Isolation of a Yersinia enterocolitica biotype 1B strain in France, and evaluation of its genetic relatedness to other European and North American biotype 1B strains. Savin C, Le Guern AS, Lefranc M, Brémont S, Carniel E, Pizarro-Cerdá J. Emerg Microbes Infect. 2018 Jul 4;7(1):121.
Humoral and cellular immune correlates of protection against bubonic plague by a live Yersinia pseudotuberculosis vaccine. Demeure CE, Derbise A, Guillas C, Gerke C, Cauchemez S, Carniel E, Pizarro-Cerdá J. Vaccine. 2019 Jan 3;37(1):123-129.
First isolation of Yersinia entomophaga in human urinary tract. Le Guern AS, Savin C, Brémont S, Payro G, Bon D, Carniel E, Pizarro-Cerdá J. New Microbes New Infect. 2018 Aug 11;26:3-7.
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Project Type : Short
Status : Closed

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