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Project #1320
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#1320 : An automatic pipeline to call SNPs from RNA-seq reads
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Organisms :
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Name of Applicant : Vincent Raquin
Date of application : 18-05-2015
Unit : Insect-Virus Interactions
Location : Fran├žois Jacob – 4th floor – 07A
Phone : 9565
@ Mail : vraquin@pasteur.fr

Project context and summary :

Dengue is an arthropod-borne viral disease caused by dengue virus (DENV), which is transmitted by Aedes mosquitoes. Recent studies estimate that 100 million cases occur annually worldwide, making dengue the most prevalent mosquito-borne viral disease of human beings. DENV transmission results from interactions between humans, mosquitoes, viruses and their environment. If the human immune response against DENV is well studied, there are knowledge gaps in understanding how mosquitoes and DENV interact with each other. Moreover, it was shown that virus transmission does not only depend on the viral strain and mosquito population but also on the specific interaction between the two partners, named genotype-by-genotype (GxG) interaction. One aim of the team is to highlight factors at the mosquito and virus levels that regulate vector competence, i.e. the ability for a mosquito to acquire viral infection and subsequently transmit the virus to a new host. To this aim, we use field-derived Aedes aegypti populations that we challenge in the lab with virus isolates from DENV infected patients. This allows us to refine our understanding of the basic biology of virus transmission by mosquitoes.


Related team publications :
Fansiri et al., PLoS Genetics (2013)
Service Delivery
Project Manager : varun.khanna@pasteur.fr
Project Type : Medium
Status : Awaiting Publication


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