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Project #13382
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#13382 : Mechanisms of HIV-1-infected cells susceptibility to Fc effector functions
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Name of Applicant : Timothée Bruel
Date of application : 25-06-2019
Unit : Virus and Immunity
Location : 22-04-17A
Phone : 0145688783
@ Mail : tbruel@pasteur.fr
@ PI-Mail : schwartz@pasteur.fr

Project context and summary :

Deconvolution of the polyclonal antibody response targeting HIV-1 allowed the identification of broadly neutralizing monoclonal antibodies (bNAbs) targeting the viral envelope. Infusion of bNAbs protects against HIV-1 acquisition and decreases viral load. bNAbs kill HIV-1-infected cells, modulate host immune responses, and, when associated to latency-reversal agents, delay viral rebound in animal models. These antiviral activities are mediated by the Fc region, which is required for optimal in vivo efficacy. Thus, the landscape of Fc effector functions triggered by bNAbs is under intense investigation. Our aim is to decipher the molecular mechanisms underlying the sensitivity of HIV-1-infected cells to Fc effector functions.


Related team publications :
Lack of ADCC Breadth of Human Nonneutralizing Anti-HIV-1 Antibodies. Bruel T, Guivel-Benhassine F, Lorin V, Lortat-Jacob H, Baleux F, Bourdic K, Noël N, Lambotte O, Mouquet H, Schwartz O. J Virol. 2017 Mar 29;91(8). pii: e02440-16. doi: 10.1128/JVI.02440-16. Print 2017 Apr 15. PMID: 28122982
Elimination of HIV-1-infected cells by broadly neutralizing antibodies. Bruel T, Guivel-Benhassine F, Amraoui S, Malbec M, Richard L, Bourdic K, Donahue DA, Lorin V, Casartelli N, Noël N, Lambotte O, Mouquet H, Schwartz O. Nat Commun. 2016 Mar 3;7:10844. doi: 10.1038/ncomms10844.
Service Delivery
Project Manager : anne.biton@pasteur.fr
Project Type : Short
Status : In Progress


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