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Project #13387
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#13387 : Distribution of Cytotoxic necrotizing factor 1 among the sequence type 131 emergent multidrug resistant lineage of Escherichia coli
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Name of Applicant : TSOUMTSA MEDA Landry Laure
Date of application : 27-06-2019
Unit : Bacterial Toxins
Location : Guerrin-1rst floor
Phone : 01 40 61 34 99
@ Mail : landry.tsoumtsa-meda@pasteur.fr
@ PI-Mail : Emmanuel.Lemichez@pasteur.fr

Project context and summary :

E. coli sequence type 131 is primarily responsible for 40-80% of extended-spectrum beta-lactamase (ESBL) infections causing million antimicrobial resistant infections annually. Population genetic analyses indicate that ST131 consists of three different sublineages, clade A, B and C, genetically defined by polymorphisms in the gene fimH (fimH41, H22 and H30, respectively). The Cytotoxic necrotizing factor 1 (CNF1) is one major Uropathogenic E. coli (UPEC) virulence factor that catalyzes a pro-oncogenic mutation on Rho GTPases and triggers pejorative inflammatory responses. E. coli ST131 were first reported to lack some UPEC key virulence factors among which CNF1 but recently we and other groups have noticed the presence of the cnf1 gene in some ST131 isolates but the occurrence of CNF1 among E. coli ST131 is still unknown and in order to better define the success of pandemic MDR E. coli the benefit of cnf1 carriage must be elucidated. To address this question, by using bio-informatics approaches the present study analyzed the distribution and the evolution of CNF1 in E. coli ST131 isolates and also examined the association between the presence of CNF1 and antibiotic resistance genes.


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Project Manager : emeline.perthame@pasteur.fr
Project Type : Short
Status : In Progress


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