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Project #13393
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#13393 : Excess calorie intake early in life increases susceptibility to colitis in the adult
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Name of Applicant : Ziad Al Nabhani
Date of application : 03-07-2019
Unit : Microenvironment and Immunity
Location : 67-RDC-24
Phone : 0140613806
@ Mail : ziad.alnabhani@pasteur.fr
@ PI-Mail : gerard.eberl@pasteur.fr

Project context and summary :

Epidemiological data report an association between obesity and inflammatory bowel disease (IBD). Furthermore, animal models demonstrate that maternal high fat diet (HFD) and maternal obesity increase susceptibility to IBD in offsprings. However, the mechanisms that translate maternal obesity and HFD into increased susceptibility to IBD later in life remain unknown. Here we report that excess calorie intake by neonatal mice, as a consequence of maternal HFD, forced feeding of neonates or low litter competition, leads to multiple causally-linked perturbations in the intestine that imprint the individual with long term susceptibility to IBD.


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Service Delivery
Project Manager : pascal.campagne@pasteur.fr
Project Type : Short
Status : In Progress


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