Project
Project #13406
Step by step one goes very far
Organisms :
Group : Name of Applicant : Priyanka Devi Date of application : 12-07-2019 Unit : Cytokine Signaling Location : Metchnikoff 67A, 5th Floor, Lab 5038 Phone : 0605541300@ Mail : priyanka.devi@pasteur.fr@ PI-Mail : sandra.pellegrini@pasteur.fr
Project context and summary :
Adaptive immune cells play important role in pathogenesis of multiple sclerosis by infiltrating the central nervous system, thereby contributing to demyelination and maintenance of an inflammatory microenvironment. In particular, autoreactive T cells, CD4+ T helper and CD8+ T cells exert a detrimental effect, while CD4+ regulatory T cells (Treg) have impaired suppressive function. Interferon b (IFNb), a commonly prescribed treatment for relapsing-remitting multiple sclerosis (RR-MS) decreases relapse rates and brain disability progression. However, around 30% of patients are or become non-responsive to treatment. Our aim is to determine the immune signatures associated with clinical efficacy of IFNb treatment in RRMS patients
Related team publications :