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Project #13406
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#13406 : Multiparametric immunophenotyping of whole blood in IFN-treated multiple sclerosis patients
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Name of Applicant : Priyanka Devi
Date of application : 12-07-2019
Unit : Cytokine Signaling
Location : Metchnikoff 67A, 5th Floor, Lab 5038
Phone : 0605541300
@ Mail : priyanka.devi@pasteur.fr
@ PI-Mail : sandra.pellegrini@pasteur.fr

Project context and summary :

Adaptive immune cells play important role in pathogenesis of multiple sclerosis by infiltrating the central nervous system, thereby contributing to demyelination and maintenance of an inflammatory microenvironment. In particular, autoreactive T cells, CD4+ T helper and CD8+ T cells exert a detrimental effect, while CD4+ regulatory T cells (Treg) have impaired suppressive function. Interferon b (IFNb), a commonly prescribed treatment for relapsing-remitting multiple sclerosis (RR-MS) decreases relapse rates and brain disability progression. However, around 30% of patients are or become non-responsive to treatment. Our aim is to determine the immune signatures associated with clinical efficacy of IFNb treatment in RRMS patients


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Project Manager : damien.mornico@pasteur.fr
Project Type : Short
Status : In Progress


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