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Project #13408
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#13408 : Proteome remodeling induces by the Cytotoxic Necrotizing Factors 1
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Name of Applicant : Landry Laure TSOUMTSA
Date of application : 15-07-2019
Unit : Bacterial Toxins
Location : Guerrin-1rst floor
Phone : 0140613499
@ Mail : landry.tsoumtsa-meda@Pasteur.fr
@ PI-Mail : emmanuel.lemichez@pasteur.fr

Project context and summary :

Urinary Tract Infections (UTIs) represent approximatively 150 to 250 million cases per year, thus are of major public health concern. 80% of community-acquired UTIs are caused by UPECs and about 40% of UPECs are known to produce the Cytotoxic Necrotizing Factors1 (CNF1). The CNF1 is a Rho-activating toxin that catalyzes a specific deamidation of a glutamine of Rho GTPases for cells invasion. The deamidation maintains the GTPases constitutively activated and the constant activation of RhoGTPases by CNF1 leads to proteasomal degradation through K48 ubiquitination. However, the change in proteins expression levels, the rate of modification induced by the CNF1 on the cellular proteome and the outcomes of host responses have not yet been investigated. By conducting quantitative mass spectrometry–based proteomics approaches, we intend to describe changes of the cellular proteome during cell invasion by UPEC producing CNF1.


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Project Manager : natalia.pietrosemoli@pasteur.fr
Project Type : Short
Status : Pending
Global Satisfaction for this application : Pretty Good (4/5)


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