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Project #13672
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#13672 : Impact of APC gene mutations on anti-tumoral immune responses
Topics :
Organisms :
Group :
Name of Applicant : Vincenzo Di Bartolo
Date of application : 11-09-2019
Unit : Lymphocyte Cell Biology
Location : Lwoff (22) – 2nd floor – room 210
Phone : 3655
@ Mail : vincenzo.di-bartolo@pasteur.fr
@ PI-Mail : andres.alcover@pasteur.fr

Project context and summary :

The aim of this project is to understand how inherited APC gene mutations affect the immune system of familial adenomatous polyposis patients, and to evaluate the potential contribution of altered immune responses to polyposis and intestinal cancer development in these patients. (see https://research.pasteur.fr/en/project/projet-de-recherche-clinique-impact-des-mutations-du-gene-apc-adenomatous-polyposis-coli-dans-les-reponses-immunes-anti-tumorales/)


Related team publications :
Agüera-González S, Burton OT, Vázquez-Chávez E, Cuche C, Herit F, Bouchet J, Lasserre R, Del Río-Iñiguez I, Di Bartolo V, Alcover A. Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization. Cell Rep. 2017 Oct 3;21(1):181-194. doi: 10.1016/j.celrep.2017.09.020. PubMed PMID: 28978472.
Service Delivery
Project Manager : pascal.campagne@pasteur.fr
Project Type : Short
Status : Pending


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