Topics : Organisms : Group : Name of Applicant :
Nadia Benaroudj Date of application :
12-11-2019 Unit :
Biology of Spirochetes Location :
12-3-16 Phone :
0140613746@ Mail :
Project context and summary :
Pathogen leptospires are responsible for the zoonotic disease leptospirosis. During infection, Leptospira are confronted with dramatic adverse environmental changes such as deadly reactive oxygen species (ROS). Defenses against ROS, e.g. peroxidase activity, are crucial for Leptospira virulence and the adaptive response to ROS is controlled by PerR regulators. We aim at studying how small non-coding RNA participate in the adaptive response to oxidative stress in pathogen Leptospira.Related team publications :
4. Kebouchi M, Saul F, Taher R, Landier A, Beaudeau B, Dubrac S, Weber P, Haouz A, Picardeau M, and Benaroudj, N. (2018) The PerR from Leptospira interrogans is a functional dimeric peroxide stress regulator devoid of a structural metal binding site. J. Biol. Chem. 293:497-509
Zhukova, A., Fernandes, L.G., Hugon, P., Pappas, C.J., Sismeiro, O., Coppée, J.-Y., Becavin, C., Malabat, C., Eshghi, A., Zhang, J.-J., et al. (2017). Genome-Wide Transcriptional Start Site Mapping and sRNA Identification in the Pathogen Leptospira interrogans. Front Cell Infect Microbiol 7, 10.
2. Picardeau M. 2017. Virulence of the zoonotic agent of leptospirosis: still terra incognita? Nat Rev Microbiol. 15(5):297-307.