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Project #14967
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#14967 : Transcriptional regulation of bacterial physiology during host-pathogen interaction
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Name of Applicant : Arnaud FIRON
Date of application : 22-01-2020
Unit : Biology of Gram-Positive Pathogens
Location : 03-01-02
Phone : +33 1 40 61 36 76
@ Mail : arnaud.firon@pasteur.fr
@ PI-Mail : patrick.trieu-cuot@pasteur.fr

Project context and summary :

The aim of this RNA-seq project is to characterize three transcriptional regulators of Streptococcus agalactiae, the main etiological agent of bacterial meningitis in neonate, and one transcriptional factor of Enterococcus faecalis, a second Gram-positive opportunistic pathogen.


Related team publications :
Devaux L, et al. Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus. PLoS Genet 14, e1007342 (2018)
Lentini G, et al. The plasminogen binding protein PbsP is required for brain invasion by hypervirulent CC17 Group B streptococci. Scientific reports 8, 14322 (2018)
Firon A, et al. The Abi-domain protein Abx1 interacts with the CovS histidine kinase to control virulence gene expression in group B Streptococcus. PLoS Pathog 9, e1003179 (2013)
Service Delivery
Project Manager : hugo.varet@pasteur.fr
Project Type : Medium
Status : Closed
Global Satisfaction for this application : Excellent (5/5)


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