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Project #15114
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#15114 : Proteomic analysis of Listeria monocytogenes molecules impacted upon exposure to Listeriolysin S
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Name of Applicant : Javier Pizarro-Cerda
Date of application : 10-03-2020
Unit : Yersinia
Location : Duclaux/Rez-de-Chaussée Haute/01A
Phone : 0145688326
@ Mail : pizarroj@pasteur.fr

Project context and summary :

Listeriolysin S (LLS) is a bacteriocin from Listeria monocytogenes that targets other Gram-positive bacteria, including Listeria monocytogenes itself. In order to understand the mechanism of action of LLS on target bacteria, we exposed the LLS-susceptible L. monocytogenes strain 10430S to the bacteriocin. We identified the proteome of the target bacteria with the goal of understanding which metabolic pathways are upregulated upon exposure to LLS.


Related team publications :
Listeriolysin S Is a Streptolysin S-Like Virulence Factor That Targets Exclusively Prokaryotic Cells In Vivo. Quereda JJ, Nahori MA, Meza-Torres J, Sachse M, Titos-Jiménez P, Gomez-Laguna J, Dussurget O, Cossart P, Pizarro-Cerdá J. mBio. 2017 Apr 4;8(2). pii: e00259-17.
Listeriolysin S: A bacteriocin from epidemic Listeria monocytogenes strains that targets the gut microbiota. Quereda JJ, Meza-Torres J, Cossart P, Pizarro-Cerdá J. Gut Microbes. 2017 Jul 4;8(4):384-391.
Bacteriocin from epidemic Listeria strains alters the host intestinal microbiota to favor infection. Quereda JJ, Dussurget O, Nahori MA, Ghozlane A, Volant S, Dillies MA, Regnault B, Kennedy S, Mondot S, Villoing B, Cossart P, Pizarro-Cerda J. Proc Natl Acad Sci U S A. 2016 May 17;113(20):5706-11.
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Status : Declined


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