Project
Project #15163
Step by step one goes very far
Organisms :
Group : Name of Applicant : Tobias Bønnelykke Date of application : 06-04-2020 Unit : Heart Morphogenesis Location : Institut Imagine Phone : 0742754484@ Mail : tbonnely@pasteur.fr@ PI-Mail : sigolene.meilhac@pasteur.fr
Project context and summary :
Left-right asymmetry of the heart is essential for establishing the double blood circulation. Impairment of left-right embryo patterning is associated with severe congenital heart defects. During embryonic development, the heart initially forms as a straight tube. While it elongates, it acquires the shape of a rightward helix, a process referred to as heart looping. Previous work suggests that dynamic signaling in the heart precursor cells are essential for heart looping completion, but so far only a few genes have been identified as asymmetrically expressed. In order to investigate the dynamic spatiotemporal patterning of heart precursors, and screen for novel players in asymmetric heart morphogenesis, we aim to perform several transcriptomic analyses.
Related team publications :