Project #15163
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#15163 : Left-right patterning of heart precursors
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Name of Applicant : Tobias B√łnnelykke
Date of application : 06-04-2020
Unit : Heart Morphogenesis
Location : Institut Imagine
Phone : 0742754484
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Project context and summary :

Left-right asymmetry of the heart is essential for establishing the double blood circulation. Impairment of left-right embryo patterning is associated with severe congenital heart defects. During embryonic development, the heart initially forms as a straight tube. While it elongates, it acquires the shape of a rightward helix, a process referred to as heart looping. Previous work suggests that dynamic signaling in the heart precursor cells are essential for heart looping completion, but so far only a few genes have been identified as asymmetrically expressed. In order to investigate the dynamic spatiotemporal patterning of heart precursors, and screen for novel players in asymmetric heart morphogenesis, we aim to perform several transcriptomic analyses.

Related team publications :
Desgrange et al., Transient Nodal signalling in left precursors coordinates opposed asymmetries shaping the heart loop. BioRxiv. 2019. DOI:
Desgrange et al., Left-right asymmetry in heart development and disease: forming the right loop. Development 2018 145: dev162776. DOI: 10.1242/dev.162776.
Le Garrec et al., A predictive model of asymmetric morphogenesis from 3D reconstructions of mouse heart looping dynamics. eLife 2017;6:e28951 . DOI: 10.7554/eLife.28951.
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Project Type : Long
Status : In Progress

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