Project #15228
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#15228 : Coaching in R
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Name of Applicant : Elisabetta Bianchi
Date of application : 24-04-2020
Unit : Immunoregulation
Location : Metchnikoff 5th floor
Phone : 01 4061 3827
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Project context and summary :

Background : The Immunoregulation Unit is composed at present of: Lab Head, one senior staff scientists, two “ingegnieurs” (one IP, one Fondation APHP), two PhD students. The focus of the research is the study of immuno-mechanisms in the pathogenesis of chronic inflammatory diseases, and of the molecular basis of response to treatment. All members of the lab have expressed an interest in acquiring basic R skills for the analysis of large gene expression data sets, collected from the study of patients’ samples. Only one PhD student in the lab is currently using R tools for data analysis, the other members have all received some previous instructions in biostatistics and/or R, but have not been using R tools currently. Requirements : Lab members have expressed a specific need to be instructed in the following areas: 1.refresh basic notions of R language, with a particular focus on handling large gene expression data sets 2.introduction to graphic tools for data representation (ggplot) 3.introduction to tools for differential gene expression analysis (limma) exploration using Principal Component Analysis Constraints : 1. For the course, it has been decided to use data generated by the lab. Placing the course in the lab’s data context has the advantage of ensuring that the course content is adapted to the “real-life” situations that lab members face in the analysis of their own data. 2.The present situation of “confinement” due to the Covid19 pandemic offers some opportunities (time availability of all members to follow the instruction), but obvious restriction. To maintain interactivity, classes are held at a distance, using Skype group meetings.

Related team publications :
Immune response profiling reveals signaling networks mediating TNF-blocker function in chronic inflammation. S. Menegatti, V. Guillemot et al. in preparation
2 Anti-TNF Therapy in Spondyloarthritis and Related Diseases, Impact on the Immune System and Prediction of Treatment Responses. Menegatti S, Bianchi E, Rogge L. Front Immunol. 2019
The IL-23/IL-17 pathway in human chronic inflammatory diseases-new insight from genetics and targeted therapies. Bianchi E, Rogge L. Genes Immun. 2019 May;20(5):415-425.
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Project Type : Coaching
Status : In Progress

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