Project #15353
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#15353 : NGS-based genetic linkage mapping in Anopheles
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Name of Applicant : Kenneth VERNICK
Date of application : 07-06-2020
Unit : Genetics and Genomics of Insect Vectors
Location : Sergent - 3rd floor
Phone : 3642
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Project context and summary :

The mechanisms underlying Anopheles mosquito susceptibility to malaria parasite infection in nature are not understood. We infected wild Anopheles pedigrees in West Africa to map loci for susceptibility to the human malaria parasite Plasmodium falciparum. Individuals from phenotyped pedigrees were entirely sequenced in order to identify and fine-map segregating loci.

Related team publications :
Nardini, L., Holm, I., Pain, A., Bischoff, E., Gohl, D.M., Zongo, S., Guelbeogo, W.M., Sagnon, N., Vernick, K.D., and Riehle, M.M. (2019). Influence of genetic polymorphism on transcriptional enhancer activity in the malaria vector Anopheles coluzzii. Sci Rep 9, 15275.
Riehle, M.M., Bukhari, T., Gneme, A., Guelbeogo, W.M., Coulibaly, B., Fofana, A., Pain, A., Bischoff, E., Renaud, F., Beavogui, A.H., et al. (2017). The Anopheles gambiae 2La chromosome inversion is associated with susceptibility to Plasmodium falciparum in Africa. Elife 6.
Mitri, C., Bischoff, E., Takashima, E., Williams, M., Eiglmeier, K., Pain, A., Guelbeogo, W.M., Gneme, A., Brito-Fravallo, E., Holm, I., et al. (2015). An Evolution-Based Screen for Genetic Differentiation between Anopheles Sister Taxa Enriches for Detection of Functional Immune Factors. PLoS Pathog 11, e1005306.
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Project Type : Medium
Status : In Progress

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