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Project #15354
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#15354 : Genetic association of malaria susceptibility by Anopheles population resequencing
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Name of Applicant : Kenneth VERNICK
Date of application : 07-06-2020
Unit : Genetics and Genomics of Insect Vectors
Location : Sergent - 3rd floor
Phone : 3642
@ Mail : kvernick@pasteur.fr

Project context and summary :

The highest global malaria prevalence is in Africa, where the most important vectors are members of the Anopheles gambiae species complex. We generated a large curated panel of infected wild Anopheles gambiae mosquitoes in West Africa to analyze for association of genetic variants with susceptibility to the human malaria parasite Plasmodium falciparum.


Related team publications :
Nardini, L., Holm, I., Pain, A., Bischoff, E., Gohl, D.M., Zongo, S., Guelbeogo, W.M., Sagnon, N., Vernick, K.D., and Riehle, M.M. (2019). Influence of genetic polymorphism on transcriptional enhancer activity in the malaria vector Anopheles coluzzii. Sci Rep 9, 15275.
Riehle, M.M., Bukhari, T., Gneme, A., Guelbeogo, W.M., Coulibaly, B., Fofana, A., Pain, A., Bischoff, E., Renaud, F., Beavogui, A.H., et al. (2017). The Anopheles gambiae 2La chromosome inversion is associated with susceptibility to Plasmodium falciparum in Africa. Elife 6.
Mitri, C., Bischoff, E., Takashima, E., Williams, M., Eiglmeier, K., Pain, A., Guelbeogo, W.M., Gneme, A., Brito-Fravallo, E., Holm, I., et al. (2015). An Evolution-Based Screen for Genetic Differentiation between Anopheles Sister Taxa Enriches for Detection of Functional Immune Factors. PLoS Pathog 11, e1005306.
Service Delivery
Project Manager : adrien.pain@pasteur.fr
Project Type : Medium
Status : Pending


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