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Project #15813
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#15813 : Identification, structural and functional analyses of peptides from SARS-Cov2 binding with high affinity to MHC-E and impact on NK cell responses in SARS-Cov2 infection
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Name of Applicant : Huot Nicolas
Date of application : 01-10-2020
Unit : HIV, Inflammation and Persistence
Location : Bat 26 f Jacob 3rd floor
Phone : +33 1 40 61 35 94
@ Mail : nicolas.huot@pasteur.fr
@ PI-Mail : michaela.muller-trutwin@pasteur.fr

Project context and summary :

We propose to identify peptides derived from the S protein that can modulate the HLA-E restricted activity of NK cells. Through in-silico analyses, we have already identified in the S protein of SARS-Cov1, SARS-Cov2 and MERS-Cov regions coding for peptides with HLA-E binding motifs. We will perform functional and structural analyses of the binding of these peptides to MHC-E. We will study MHC-E restricted responses of NK cells in blood and tissues during SARS-Cov2 infection in non human primates. From longitudinally collected samples from blood and tissues before and after the SARS-CoV2 infection of the animals, we will analyse the phenotype and transcriptome profile of NK cells and compare to viral loads and disease progression of the animals.


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Project Manager : amine.ghozlane@pasteur.fr
Status : Pending


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