Project #15813
Step by step one goes very far

Logged as guest

Go Back to Project List
#15813 : Identification, structural and functional analyses of peptides from SARS-Cov2 binding with high affinity to MHC-E and impact on NK cell responses in SARS-Cov2 infection
Topics :
Organisms :
Group :
Name of Applicant : Huot Nicolas
Date of application : 01-10-2020
Unit : HIV, Inflammation and Persistence
Location : Bat 26 f Jacob 3rd floor
Phone : +33 1 40 61 35 94
@ Mail :
@ PI-Mail :

Project context and summary :

We propose to identify peptides derived from the S protein that can modulate the HLA-E restricted activity of NK cells. Through in-silico analyses, we have already identified in the S protein of SARS-Cov1, SARS-Cov2 and MERS-Cov regions coding for peptides with HLA-E binding motifs. We will perform functional and structural analyses of the binding of these peptides to MHC-E. We will study MHC-E restricted responses of NK cells in blood and tissues during SARS-Cov2 infection in non human primates. From longitudinally collected samples from blood and tissues before and after the SARS-CoV2 infection of the animals, we will analyse the phenotype and transcriptome profile of NK cells and compare to viral loads and disease progression of the animals.

Related team publications :
Service Delivery
Project Manager :
Status : Pending

Go Back to Project List

Sorry. You must be logged in to view this form.