Project

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Name of Applicant : Pablo Canales Herrerias
Date of application : 11-12-2020
Unit : Antibodies in Therapy and Pathology
Location : Metchnikoff - 2nd floor
Phone : +33140613976
@ Mail : pablo.canalesherrerias@pasteur.fr
@ PI-Mail : pierre.bruhns@pasteur.fr

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Project context and summary :

Immune thrombocytopenia (ITP) is an autoimmune condition characterized by an autoantibody response against platelets, driven by pathogenic plasma cells often found in the spleen. This autoreactive plasma cell population remains poorly characterized, especially in terms of antibody affinity and anatomical distribution. In order to tackle this problem, we have developed a microfluidic platform to characterize platelet-specific plasma cells isolated from ITP patients, in terms of their IgG secretion rate and affinity for a platelet autoantigen at the single-cell level.

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