Project #16822
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#16822 : Genome analysis of the immunostimulatory commensal SFB
Topics :
Organisms :
Group :
Name of Applicant : Pamela Schnupf
Date of application : 09-03-2021
Unit :
Location : Building Francois Jacob, etage -1, Ultrastructural Imaging Platform (UBI) Institut Pasteur, 28 rue du Dr Roux 75724 PARIS CĂ©dex 15, France
Phone : 0698399692
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Project context and summary :

The gut microbiota is instrumental in stimulating, shaping and educating the host immune system, both in and outside of the gut. One of the most immunostimulatory commensals identified to date is the unusual bacterium Segmented Filamentous Bacteria (SFB). SFB intimately attaches to absorptive epithelial cells in the ileum after weaning in a host-specific manner. We aim to do compare the genomes of SFB from a range of vertebrate species to identify shared and strain-specific differences that may bring insights into their niche adaptations.

Related team publications :
Schnupf et al. 2015 Nature doi: 10.1038/nature14027
Nkamba et al. 2020 Nature Microbiology doi: 10.1038/s41564-019-0608-1
Schnupf et al. 2017 Current Opinion in Microbiology doi: 10.1016/j.mib.2017.03.004
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Status : Closed

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