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Project #17289
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#17289 : Mosquito vector competence for Zika virus
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Name of Applicant : Anna-Bella FAILLOUX
Date of application : 22-07-2021
Unit : Arboviruses and Insect Vectors
Location : nicolle 1st floor
Phone : 0140613617
@ Mail : anna-bella.failloux@pasteur.fr

Project context and summary :

Before the WHO considered it as a public health emergency of international concern in February 2016, Zika virus (ZIKV, Flavivirus, Flaviviridae) was a neglected mosquito-borne virus. First identified in Uganda in a sylvatic cycle, ZIKV has caused in few months millions cases, emerging in the five continents (Latin America, the Caribbean, Southeast Asia/Pacific Ocean, Africa/Indian Ocean, European countries (Portugal, Spain, France, Switzerland, the Netherlands)). We have initiated the most comprehensive study on vector competence with almost 50 mosquito populations belonging to five main species (Aedes aegypti, Aedes albopictus, Aedes japonicus, Culex pipiens, Culex quinquefasciatus) infected with 3 different ZIKV and examined at 3 days post-infection (7, 14, and 21). The objective of the project will be to run a meta analysis on vector competence and to assess to which extent each mosquito species contributes to ZIKV transmission according to the geographical location and the viral genotype. It will help to improve our understanding of the vector status and adapt surveillance, prevention, and control of Zika.


Related team publications :
Vazeille M, Madec Y, Mousson L, Bellone R, Barré-Cardi H, Sousa CA, Jiolle D, Yébakima A, de Lamballerie X, Failloux AB. Zika virus threshold determines transmission by European Aedes albopictus mosquitoes. Emerg Microbes Infect. 2019;8(1):1668-1678. doi: 10.1080/22221751.2019.1689797. PMID: 31735122; PMCID: PMC6882490.
Mariconti M, Obadia T, Mousson L, Malacrida A, Gasperi G, Failloux AB, Yen PS. Estimating the risk of arbovirus transmission in Southern Europe using vector competence data. Sci Rep. 2019 Nov 28;9(1):17852. doi: 10.1038/s41598-019-54395-5. PMID: 31780744; PMCID: PMC6882796.
Jupille H, Seixas G, Mousson L, Sousa CA, Failloux AB. Zika Virus, a New Threat for Europe? PLoS Negl Trop Dis. 2016 Aug 9;10(8):e0004901. doi: 10.1371/journal.pntd.0004901. PMID: 27505002; PMCID: PMC4978396.
Service Delivery
Project Manager : thomas.obadia@pasteur.fr
Status : Pending


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