Topics : Organisms : Group : Name of Applicant :
Elisabetta Bianchi Date of application :
04-10-2021 Unit :
Immunoregulation Location :
metchnikoff 5th floor Phone :
40613827@ Mail :
email@example.com@ PI-Mail :
Project context and summary :
Chronic inflammatory diseases (CID) are clinically heterogeneous conditions that share common inflammatory pathways and derive from aberrant immune responses. Genome-wide association studies (GWAS), together with mouse models of autoimmune disease, demonstrated the implication of the IL-23 cytokine pathway in several CID. The overall goal of our work is to improve our understanding of the role of IL-23 in the pathophysiology of CIDs, such as axial spondyloarthritis, psoriatic arthritis, and psoriasis. The specific question we want to address with this project is how is expression of the IL-23 receptor regulated in T cell populations.Related team publications :
S. Menegatti, V. Guillemot, E. Latis, H. Yahia-Cherbal, D. Mittermüller, V. Rouilly, E. Mascia, N. Rosine, S. Koturan, G. A. Millot, C. Leloup, D. Duffy, A. Gleizes, S. Hacein-Bey-Abina, Milieu Interieur Consortium, J. Sellam, F. Berenbaum, C. Miceli-Richard, M. Dougados, E. Bianchi, L. Rogge. Ann Rheum Dis. 2020 Dec 2;80(4):475-86. doi: 10.1136/annrheumdis-2020-218304. Online ahead of print (2020).
Yahia-Cherbal, H, Rybczynska M, Lovecchio D, Stephan T, Lescoat C, Placek K, Larghero J, Rogge L, Bianchi E* NFAT primes the human RORC locus for RORt expression in CD4+ T cells Nature Communications, 2019;10(1):4698.
Bianchi E, Rogge L. The IL-23/IL-17 pathway in human chronic inflammatory diseases-new insight from genetics and targeted therapies. Genes Immun. 2019 May;20(5):415-425. doi: 10.1038/s41435-019-0067-y.