Project

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Name of Applicant : Romain Levayer
Date of application : 26-11-2021
Unit : Cell death and epithelial homeostasis
Location : Monod, 5th floor
Phone : 06 75 22 64 90
@ Mail : romain.levayer@pasteur.fr

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Project context and summary :

We have performed a systemic characterisation of apoptosis distribution and clone dynamics in the Drosophila wing imaginal disc. Surprisingly, we outlined a systematic spatial bias in the rate of apoptosis with regions shoing high rates of apoptosis which correlate with high probability of clone disappearance and small clone size. We would like to formulate analytically the prediction of local clone size assuming a homogenous proliferation rate and knowing spatial differences in clone disappearance probability. This will help to evaluate how much the spatial differences in apoptic rates are sufficient to explain the differences in local growth.

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