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Project #19102
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#19102 : Exploring pathogenic mechanisms of chronic inflammatory disease: unresolved issues in IL-23/IL-17 biology
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Organisms :
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Name of Applicant : YAHIA Hanane
Date of application : 28-03-2022
Unit : Immunoregulation
Location : 67-05-22
Phone : 01 40 61 32 30
@ Mail : hanane.yahia@pasteur.fr
@ PI-Mail : lars.rogge@pasteur.fr

Project context and summary :

Chronic inflammatory diseases (CID) are clinically heterogeneous conditions that share common inflammatory pathways and derive from aberrant immune responses. Genome-wide association studies (GWAS) demonstrated that Th17 cells play a pivotal role in the pathogenesis of these diseases and several loci involved in the IL-23/IL-17 are associated with the CID (IL23R, IL12B, IL6R, IL1R2, RORC, RUNX3, TYK2, JAK2, CARD9). IL-23 is important for the expansion and the functional activity of the Th17 cell subset and several studies have suggested that IL-23 may also regulate the function of IL-17-producing innate immune cells, which express the IL-23 receptor (IL-23R). The overall goal of this project is to improve our understanding of the so-called “IL-23/IL-17 axis” in the pathophysiology of CID and in particular to understand the effects of IL-23 on distinct cell populations and how is the expression of the IL-23 receptor regulated.


Related team publications :
Rosine N, Rowe H, Koturan S, Yahia-Cherbal H, Leloup C, Watad A, Berenbaum F, Sellam J, Dougados M, Aimanianda V, Cuthbert R, Bridgewood C, Newton D, Bianchi E, Rogge L, McGonagle D, Miceli-Richard C. Characterization of Blood Mucosal Associated Invariant T (MAIT) cells in Axial Spondyloarthritis and of resident MAITs from control axial enthesis. Arthritis Rheumatol. 2022 Feb 14. doi: 10.1002/art.42090. Epub ahead of print. PMID: 35166073.
Mezghiche I, Yahia-Cherbal H, Rogge L, Bianchi E. Novel approaches to develop biomarkers predicting treatment responses to TNF-blockers. Expert Rev Clin Immunol. 2021 Apr;17(4):331-354. doi: 10.1080/1744666X.2021.1894926. Epub 2021 Apr 23. PMID: 33622154.
Menegatti S, Guillemot V, Latis E, Yahia-Cherbal H, Mittermüller D, Rouilly V, Mascia E, Rosine N, Koturan S, Millot GA, Leloup C, Duffy D, Gleizes A, Hacein-Bey-Abina S; Milieu Intérieur Consortium, Sellam J, Berenbaum F, Miceli-Richard C, Dougados M, Bianchi E, Rogge L. Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo. Ann Rheum Dis. 2020 Dec 2;80(4):475–86. doi: 10.1136/annrheumdis-2020-218304. Epub ahead of print. PMID: 33268443; PMCID: PMC7958106.
Service Delivery
Project Manager : natalia.pietrosemoli@pasteur.fr
Project Type : Short
Status : In Progress


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