Project #19121
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#19121 : Understanding the mode of action of epigenetic inhibitors active against Plasmodium falciparum
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Name of Applicant : Irina Dobrescu
Date of application : 06-04-2022
Unit : Biology of Host-parasite Interactions
Location : Nicolle -2nd floor - room 2
Phone : 0140613507
@ Mail :
@ PI-Mail :

Project context and summary :

We are working on malaria drug discovery. In an attempt to understand the mode of action of epigenetic inhibitors active against Plasmodium falciparum, we culture the parasite under drug pressure to induce drug resistance, along with a control treated in the same conditions with the solvent only. We then clone resistant and control parasite lines and sequence their genomes to compare them to try to understand which gene is responsible for the resistance and thus may constitute the inhibitor's target (through SNPs, amplification of gene copies).

Related team publications :
Nardella F, Halby L, Dobrescu I, Viluma J, Bon C, Claes A, Cadet-Daniel V, Tafit A, Roesch C, Hammam E, Erdmann D, Mairet-Khedim M, Peronet R, Mecheri S, Witkowski B, Scherf A, Arimondo PB. Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites. J Med Chem. 2021 Jul 22;64(14):10403-10417. doi: 10.1021/acs.jmedchem.1c00821. Epub 2021 Jun 29. PMID: 34185525.
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Project Type : Medium
Status : Pending

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