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Project #19128
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#19128 : Evaluation of a novel mouse model for Primary Antibody Deficiency (PAD)
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Organisms :
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Name of Applicant : Lise Hunault
Date of application : 13-04-2022
Unit : Antibodies in Therapy and Pathology
Location : Metchnikoff, 4th floor, room 4008
Phone : +33688906562
@ Mail : lise.hunault@pasteur.fr
@ PI-Mail : pierre.bruhns@pasteur.fr

Project context and summary :

Previous animal models of Primary Antibody Deficiency (PAD) display severe dysbiosis and gut inflammation, which makes them incompatible to study a wide spectrum of PAD (e.g., most IgAD subjects display only mild dysbiosis and are asymptomatic). We would like to evaluate a novel mouse model of PAD and then perform microbiome transplant and IgA supplementation. The first objective is to evaluate the causal role of the microbiome in mediating PAD-associated disease. Our second objective is to apply an IgA supplement to reverse gut dysbiosis in symptomatic PAD and look at the microbiome changes caused by supplementation.


Related team publications :
Sterlin D, Fieschi C, Malphettes M, Larsen M, Gorochov G, Fadlallah J. Immune/microbial interface perturbation in human IgA deficiency. Gut Microbes. 2019;10(3):429-433. doi: 10.1080/19490976.2018.1546520. Epub 2018 Nov 18. PMID: 30449244; PMCID: PMC6546332.
Sterlin D, Fieschi C, Malphettes M, Larsen M, Gorochov G, Fadlallah J. Immune/microbial interface perturbation in human IgA deficiency. Gut Microbes. 2019;10(3):429-433. doi: 10.1080/19490976.2018.1546520. Epub 2018 Nov 18. PMID: 30449244; PMCID: PMC6546332.
Service Delivery
Project Manager : amine.ghozlane@pasteur.fr
Project Type : Coaching
Status : In Progress


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