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Project #19216
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#19216 : Evolution towards bipartite genome - core genes distribution in monochromosomal and bichromosomal Paracoccus species
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Name of Applicant : Jakub Czarnecki
Date of application : 19-05-2022
Unit : Bacterial Genome Plasticity
Location : Ducleaux - 2 - 27A
Phone : 0769616930
@ Mail : jakub.czarnecki@pasteur.fr
@ PI-Mail : didier.mazel@pasteur.fr

Project context and summary :

The genus Paracoccus (Alphaproteobacteria) includes bacteria carrying genomes of very different structure - from unichromosomal strains containing no plasmids (P. suum), through strains possesing multiple extrachromosomal replicons of medium size (hundreds kb) and different nature (megaplasmids and chromids) (e.g. P. aminophilus, P. yeei or P. marcusii), to strains having a large well-constituted chromosome 2 (a chromid of over 1.5 Mb with high density of housekeeping genes), which are found in one sub-clade of the genus (including P. denitrificans, P. versutus and P. pantotrophus). In this project, we would like to follow the distribution of the core genes in all available Paracoccus genomes to uncover the events that led to the formation of chromosome 2 in this group of bacteria. At the same time, we would like to check if the core genes are preferentially found in certain localization in the genome (relatively to ori and ter of the chromosomes), possibly indicating the advantages of the bipartite genomes found in some Paracoccus species.


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