Project #2237
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#2237 : Candida albicans population genomics
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Name of Applicant : Christophe d'Enfert
Date of application : 01-06-2015
Unit : Fungal Biology and Pathogenicity
Location : Fernbach - 4 - 28A
Phone : +33140613257
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Project context and summary :

Candida albicans is responsible for the majority of life-threatening fungal infections occurring in hospitalized patients and is also the most frequently isolated fungal commensal of humans. The C. albicans population includes at least 18 phylogenetic groups (or clades). Specific phenotypes can distinguish isolates within a given clade from those in other clades and yet, the relationships between C. albicans natural genetic and phenotypic diversities have not been explored in depth. We have sequenced the diploid genomes of >150 C. albicans isolates selected from a collection of commensal/clinical isolates previously used to characterize the population structure and belonging to the 12 major C. albicans clades. The aim of this project is to develop the tools necessary for an in depth analysis of these genome sequences in order to allow us ask questions about the extent of C. albicans genetic diversity, the contribution of loss-of-heterozygosity to this diversity, and the history of C. albicans population.

Related team publications :
Odds, F. C., Bougnoux, M. E., Shaw, D. J., Bain, J. M., Davidson, A. D., Diogo, D., Jacobsen, M. D., Lecomte, M., Li, S. Y., Tavanti, A., Maiden, M. C., Gow, N. A. and d\'Enfert, C. (2007) Molecular phylogenetics of Candida albicans. Eukaryot Cell 6: 1041-1052.
Calderón-Noreña, D.M., González-Novo, A., Orellana-Muñoz, S., Gutiérrez-Escribano, P., Arnáiz-Pita, Y., Dueñas-Santero, E., Suárez, M.B., Bougnoux, M.E., Del Rey, F., Sherlock, G., d\'Enfert, C., Correa-Bordes, J., and de Aldana, C.R. (2015) A single nucleotide polymorphism uncovers a novel function for the transcription factor Ace2 during Candida albicans hyphal development. PLoS Genet 11, e1005152.
Diogo, D., Bouchier, C., d\'Enfert, C. and Bougnoux, M.E. (2009) Loss of heterozygosity in commensal isolates of the asexual diploid yeast Candida albicans. Fungal Genet Biol 46: 159-168.
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Project Type : Long
Status : In Progress

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