Project #2239
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#2239 : Characterization of microevolution in Candida albicans isolates
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Name of Applicant : Christophe d'Enfert
Date of application : 01-06-2015
Unit : Fungal Biology and Pathogenicity
Location : Fernbach - 4 - 28A
Phone : +33140613257
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Project context and summary :

Candida albicans is responsible for the majority of life-threatening fungal infections occurring in hospitalized patients and is also the most frequently isolated fungal commensal of humans. Microevolution of C. albicans isolates has been observed in a number of instances, being in particular characterized by loss-of-heterozygosity events. Yet, most studies that have investigated such microevolutions have not used whole-genome sequencing. In this project, we aim to characterize C. albicans microevolution at the genome-wide level. To this aim, we will take advantage of multiple isolates collected at the same time in healthy individuals and that share the same molecular type, thus providing information on the extent of genetic diversity of commensal isolates. We will also take advantage of series of isolates collected in patients with different forms of candidiasis and/or that have received antifungal therapy, thus providing information of the impact of pathogenic interaction and antifungal treatment on genome dynamics.

Related team publications :
Bougnoux, M. E., Diogo, D., Francois, N., Sendid, B., Veirmeire, S., Colombel, J. F., Bouchier, C., Van Kruiningen, H., d\'Enfert, C. and Poulain, D. (2006) Multilocus sequence typing reveals intrafamilial transmission and microevolutions of Candida albicans isolates from the human digestive tract. J Clin Microbiol 44: 1810-1820.
Angebault, C., Djossou, F., Abélanet, S., Permal, E., Ben Soltana, M., Diancourt, L., Bouchier, C., Woerther, P.-L., Catzeflis, F., Andremont, A., d’Enfert, C., and Bougnoux, M.E. (2013) Candida albicans is not always the preferential yeast colonising humans: a study amongst Wayampi Amerindians. J Infect Dis 208: 1705-1716.
Diogo, D., Bouchier, C., d\'Enfert, C. and Bougnoux, M.E. (2009) Loss of heterozygosity in commensal isolates of the asexual diploid yeast Candida albicans. Fungal Genet Biol 46: 159-168.
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Project Type : Long
Status : Closed
Publication : doi: 10.1093/jac/dkz537; doi: 10.1038/s41598-019-38768-4

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