Project #2240
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#2240 : search for transcrition factors upregulating Tgfb1 expression in FHL2-/- cells
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Name of Applicant : Yu Wei
Date of application : 02-06-2015
Unit : Hepacivirus and Innate Immunity
Location : Lwoff, 218, 2ème étage
Phone : 0145688866
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Project context and summary :

We observed that Tgfb1 is upregulated at the transcription level in cells deficient for the four and a half LIM-only protein 2 (FHL2). The upregulation of Tgfb1 leads to increased liver and kidney fibrogenesis in FHL2-/- mice. We have carried out microarray analysis with mouse embryonic fibroblasts derived from FHL2-/- embryos. We would like to have help for the analysis of our microarray data to identify the transcription factors that would be responsible for the upregulation of Tgfb1 expression in FHL2-/- cells. These transcription factors should potentially bind to the murine promoter of Tgfb1.

Related team publications :
Xia, T., Levy, L., Levillayer, F., Jia, B., Li, G., Neuveut, C., Buendia, M. A., Lan, K., and Wei, Y. 2013. The four and a half LIM-only protein 2 (FHL2) activates transforming growth factor beta (TGF-beta) signaling by regulating ubiquitination of the E3 ligase Arkadia. J Biol Chem 288:1785-1794.
Nouet, Y., Dahan, J., Labalette, C., Levillayer, F., Julien, B., Jouvion, G., Cairo, S., Vives, F. L., Ribeiro, A., Huerre, M., Colnot, S., Perret, C., Nhieu, J. T., Tordjmann, T., Buendia, M. A., and Wei, Y. 2012. The four and a half LIM-only protein 2 regulates liver homeostasis and contributes to carcinogenesis. J Hepatol 57:1029-1036.
Dahan, J., Nouet, Y., Jouvion, G., Levillayer, F., Adib-Conquy, M., Cassard-Doulcier, A. M., Tebbi, A., Blanc, F., Remy, L., Chen, J., Cairo, S., Werts, C., Si-Tahar, M., Tordjmann, T., Buendia, M. A., and Wei, Y. 2013. LIM-only protein FHL2 activates NF-kappaB signaling in the control of liver regeneration and hepatocarcinogenesis. Mol Cell Biol 33:3299-3308.
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Project Type : Short
Status : Closed

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